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About Dr Chris Sharp

After graduating I worked in the chemical industry before relocating to Shropshire to take up a research post in connective tissue biochemistry at a specialist orthopaedic hospital. After completing a post-graduate research studentship at Manchester University I undertook a period of post-doctoral research training in Finland investigating crosslinked collagen telopeptide structures and how various components of the collagen molecule could be used as markers of collagen turnover in metabolic bone disease.  Following this, on my return to the UK I undertook research into metabolic bone disease which led to a sabbatical period at Linkoping University in Sweden.  This work involved the characterisation of recently discovered, novel bone-specific isoforms of alkaline phosphatase, a enzyme important in bone formation. On returning to the UK I undertook clinical research into various aspects of the musculo-skeletal health and was also involved with NHS service management. After leaving the NHS I worked with a newly established biotech company developing and producing products for use in veterinary orthopaedics. I am currently a senior lecturer at University Centre Shrewsbury and currently lead the biochemistry and genetics & evolution programmes. I have active interests in world-wide travel, when and where-ever possible, including mountaineering or old bones and palaeontology.

Teaching

Chris is module lead for several modules including MD4302 Molecules of Life; MD4306 Essential Physiology; MD5015 Metabolism;  MD6007 Protein Interactions and MD6004 Biological Membranes and also contributes to teaching on several other undergraduate modules at University Centre Shrewsbury.

Research

Chris’s research interests include bone health, bone and intervertebral disc biochemistry. He has published more than 50 peer-reviewed scientific papers.  

Published Work

Worsfold M, Sharp CA, Davie MWJ. (1988) Serum osteocalcin and other indices of bone formation: an 8-decade population study in healthy men and women.  Clin Chim Acta 178:225-236.
Oginni LM, Worsfold M, Oyelami OA, Sharp CA, Powell DE, Davie MWJ.  Etiology of rickets in Nigerian children. J Pediatr (1996) 128:692-694.
Sharp CA, Evans SF, Risteli L, Risteli J, Worsfold M, Davie MWJ.  Effects of low and conventional dose transcutaneous HRT over 2 years on metabolism in younger and older postmenopausal women. Euro J Clin Invest (1996) 26:763-771.
Oginni LM, Sharp CA, Worsfold M, Badru OS, Davie MWJ. (1999) The healing of rickets following calcium supplementation. Lancet (Research Letter) 353:296-297.  
Magnusson P, Larsson L, Magnusson M, Davie MWJ, Sharp CA. (1999)  Isoforms of  bone alkaline phosphatase: characterisation and origin in human trabecular and cortical bone. J Bone Min Res 14:1926-1933.
Brown SJ, Pollintine P, Powell DE, Davie MWJ, Sharp CA. (2002) Regional differences in mechanical and material properties of femoral head trabecular bone in health and osteoarthritis. Calcif Tissue Int 71:227-234.
Eriksen HA, Sharp CA, Robins SP, Sassi M-L, Risteli L, Risteli J.  (2004)  Differently cross-linked and uncross-linked carboxyterminal telopeptides of type I collagen in human mineralised bone.  Bone 34: 720-727.  
Sharp CA, Linder C, Magnusson P. (2007) Analysis of human bone alkaline phosphatase isoforms: comparison of isoelectric focusing and ion-exchange high performance liquid chromatography. Clin Chem Acta 379:105-112.
Macdonald JH, Evans SF, Davie MWJ, Sharp CA. (2007) Muscle mass deficits are associated with bone mineral density in men with idiopathic vertebral fracture. Osteop Int 18:1371-1378.
Sharp CA, Roberts S, Evans H, Brown SJ. (2009) Disc cell clusters in pathological human intervertebral discs are associated with increased stress protein immunostaining. Eur Spine J 18:1587-1594.
Macdonald JH, Evans SF, Davies HL, Wilson S, Davie MWJ, Sharp CA. (2012) Matched-cohort study of body composition, physical function, and quality of life in men with idiopathic vertebral fracture. Arth Care Res 64:92-100. 
Wilson S, Sharp CA, Davie MWJ. (2012)  Health-related quality of life in patients with osteoporosis in the absence of vertebral fracture: a systematic review. Osteop Int 23:2749-68. 
Sharp CA, Magnusson P, Davie MWJ, Oginni LM. (2014) We are what we eat is it time to reconsider calcium-deficiency rickets in Nigeria?  Trop Med Intl Health 20:408-410.
Davie M, Evans S, Sharp C. (2016) Limb muscle and bone in coeliac disease.                                                                             Alimentary Pharmacology & Therapeutics 42(11-12):1332-1333
Brown S, Rodrigues S, Sharp C, Wade K, Broom N, McCall IW, Roberts S. (2017) Staying connected: structural integration at the intervertebral disc–vertebra interface of human lumbar spines. Eur Spine J 26:248-258.

Qualifications

BSc Hons Biochemistry, University College, Cardiff
PhD Chemistry, Victoria University of Manchester