Skip to content

About Dr Elizabeth O'Brien

I completed my first degree and worked for several years in the NHS as a Biomedical Scientist. I then completed my PhD researching the mechanisms and regulation of bone resorption. I came to work at University Centre Shrewsbury when it opened to its first students in 2015 as a lecturer in the Bioscience Department.

Teaching

Programme lead for Medical Genetics and Medical Science

Modules I lead/teach on:

MD4303 Cell Biology

MD4306  Essential Physiology

MD5001 Biology of Disease

MD5008 Cell Signalling

MD5014 Genetics

MD5006 Work Based Learning

MD6006 Genetics and Ageing

MD6009 Current topics in Medical Genetics

Research

My research focussed on the cell biology of osteoclasts in bone resorption and how regulation of this process might ameliorate bone loss in later life.

Published Work

Marshall, MJ, O’Brien, EA, and Holt, I. (1998). Integrins are involved in the movement of osteoclasts between the periosteum and the bone surface. Bone 22 (Suppl. 3 abstract C115). Seventh Workshop on Cell Biology of Bone and Cartilage in Health and Disease.

O’Brien, EA, Williams, JHH, and Marshall, MJ. (1999). Osteoclast differentiation factor controls the translocation of osteoclasts from the periosteum to the bone surface in mouse calvaria. Calcified Tissue International 64 (Suppl. 1 abstract 0-35) XXVth European Symposium on Calcified Tissues, Maastricht, Holland.

O’Brien, EA, Williams, JHH, and Marshall, MJ. (1999) Osteoprotegerin causes osteoclasts to detach from the surface of mouse parietal bone and adhere to the adjacent periosteum. Journal of Bone and Mineral Research 14(6) abstract P04. Bone and Tooth Spring Meeting June 1999. Winner of prize for Best Poster Presentation.

O’Brien, EA, Rowlands, MN, and Marshall, MJ. (2000). Differential adhesion of the osteoclast between the periosteum and the bone surface is regulated by osteoclast differentiation factor and osteoprotegerin. Bone 26 (Suppl. 3 abstract C62) Eighth Workshop on Cell Biology of Bone and Cartilage in Health and Disease Davos.

Rowlands, MN, O’Brien, EA, Sharp, CA, and Marshall, MJ. (2000) Formulation of tartrate-resistant-acid-phosphatase positive osteoclast-like cells in response to osteoclast differentiation factor and macrophage colony stimulating factor. Calcified Tissue International 66 (Suppl. 1 P222). XXVII European Symposium of Calcified Tissues, Tampere, Finland.

O’Brien, EA, Marshall, MJ. (2000) Osteoprotegerin is produced when prostaglandin synthesis is inhibited causing osteoclasts to detach form the surface of bone and attach to the periosteum. Journal of Bone and Mineral Research 15 (6) (Abstract P77) Bone and Tooth Spring Meeting June Cambridge.

O’Brien, EA, Williams, JHH, and Marshall, MJ. (2000) Osteoprotegerin ligand regulates osteoclast adherence to the bone surface in mouse calvaria. Biochemical and Biophysical Research Communications 274: 281-290

O’Brien, EA, Williams, JHH and Marshall, MJ. (2001) Osteoprotegerin is produced when prostaglandin synthesis is inhibited causing osteoclasts to detach from the surface of mouse parietal bone and attach to the endocranial membrane. Bone 28. 2 208-214.

Qualifications

BSc (Hons) Biomedical Science PhD